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Chapters (209)
  1. Title Page
  2. Copyright Notice
  3. Dedication
  4. PART 1
  5. CHAPTER 1
  6. CHAPTER 2
  7. CHAPTER 3
  8. INTERLUDE 1
  9. CHAPTER 4
  10. INTERLUDE 2
  11. CHAPTER 5
  12. INTERLUDE 3
  13. CHAPTER 6
  14. CHAPTER 7
  15. INTERLUDE 4
  16. CHAPTER 8
  17. CHAPTER 9
  18. CHAPTER 10
  19. CHAPTER 11
  20. CHAPTER 12
  21. CHAPTER 13
  22. INTERLUDE 5
  23. CHAPTER 14
  24. INTERLUDE 6
  25. PART 2
  26. CHAPTER 15
  27. INTERLUDE 7
  28. CHAPTER 16
  29. CHAPTER 17
  30. CHAPTER 18
  31. CHAPTER 19
  32. INTERLUDE 8
  33. CHAPTER 20
  34. CHAPTER 21
  35. CHAPTER 22
  36. CHAPTER 23
  37. CHAPTER 24
  38. CHAPTER 25
  39. CHAPTER 26
  40. CHAPTER 27
  41. CHAPTER 28
  42. CHAPTER 29
  43. CHAPTER 30
  44. CHAPTER 31
  45. CHAPTER 32
  46. INTERLUDE 9
  47. CHAPTER 33
  48. CHAPTER 34
  49. CHAPTER 35
  50. PART 3
  51. CHAPTER 36
  52. CHAPTER 37
  53. CHAPTER 38
  54. CHAPTER 39
  55. CHAPTER 40
  56. CHAPTER 41
  57. CHAPTER 42
  58. CHAPTER 43
  59. CHAPTER 44
  60. CHAPTER 45
  61. CHAPTER 46
  62. INTERLUDE 10
  63. CHAPTER 47
  64. CHAPTER 48
  65. CHAPTER 49
  66. CHAPTER 50
  67. CHAPTER 51
  68. INTERLUDE 11
  69. CHAPTER 52
  70. CHAPTER 53
  71. CHAPTER 54
  72. CHAPTER 55
  73. CHAPTER 56
  74. CHAPTER 57
  75. INTERLUDE 12
  76. CHAPTER 58
  77. CHAPTER 59
  78. CHAPTER 60
  79. CHAPTER 61
  80. CHAPTER 62
  81. CHAPTER 63
  82. CHAPTER 64
  83. CHAPTER 65
  84. CHAPTER 66
  85. CHAPTER 67
  86. CHAPTER 68
  87. CHAPTER 69
  88. CHAPTER 70
  89. CHAPTER 71
  90. PART 4
  91. CHAPTER 72
  92. CHAPTER 73
  93. CHAPTER 74
  94. CHAPTER 75
  95. INTERLUDE 13
  96. CHAPTER 76
  97. CHAPTER 77
  98. CHAPTER 78
  99. CHAPTER 79
  100. CHAPTER 80
  101. CHAPTER 81
  102. INTERLUDE 14
  103. CHAPTER 82
  104. CHAPTER 83
  105. CHAPTER 84
  106. CHAPTER 85
  107. CHAPTER 86
  108. PART 5
  109. CHAPTER 87
  110. CHAPTER 88
  111. CHAPTER 89
  112. CHAPTER 90
  113. CHAPTER 91
  114. CHAPTER 92
  115. CHAPTER 93
  116. CHAPTER 94
  117. CHAPTER 95
  118. CHAPTER 96
  119. CHAPTER 97
  120. CHAPTER 98
  121. CHAPTER 99
  122. CHAPTER 100
  123. CHAPTER 101
  124. CHAPTER 102
  125. CHAPTER 103
  126. CHAPTER 104
  127. CHAPTER 105
  128. CHAPTER 106
  129. CHAPTER 107
  130. CHAPTER 108
  131. CHAPTER 109
  132. CHAPTER 110
  133. CHAPTER 111
  134. CHAPTER 112
  135. CHAPTER 113
  136. CHAPTER 114
  137. CHAPTER 115
  138. CHAPTER 116
  139. PART 6
  140. CHAPTER 117
  141. CHAPTER 118
  142. CHAPTER 119
  143. CHAPTER 120
  144. CHAPTER 121
  145. CHAPTER 122
  146. CHAPTER 123
  147. CHAPTER 124
  148. CHAPTER 125
  149. CHAPTER 126
  150. CHAPTER 127
  151. CHAPTER 128
  152. CHAPTER 129
  153. CHAPTER 130
  154. CHAPTER 131
  155. CHAPTER 132
  156. CHAPTER 133
  157. CHAPTER 134
  158. CHAPTER 135
  159. CHAPTER 136
  160. CHAPTER 137
  161. CHAPTER 138
  162. CHAPTER 139
  163. CHAPTER 140
  164. CHAPTER 141
  165. CHAPTER 142
  166. PART 7
  167. CHAPTER 143
  168. CHAPTER 144
  169. CHAPTER 145
  170. CHAPTER 146
  171. CHAPTER 147
  172. CHAPTER 148
  173. CHAPTER 149
  174. CHAPTER 150
  175. CHAPTER 151
  176. CHAPTER 152
  177. CHAPTER 153
  178. CHAPTER 154
  179. CHAPTER 155
  180. CHAPTER 156
  181. CHAPTER 157
  182. CHAPTER 158
  183. CHAPTER 159
  184. CHAPTER 160
  185. CHAPTER 161
  186. CHAPTER 162
  187. CHAPTER 163
  188. CHAPTER 164
  189. CHAPTER 165
  190. CHAPTER 166
  191. CHAPTER 167
  192. CHAPTER 168
  193. CHAPTER 169
  194. CHAPTER 170
  195. CHAPTER 171
  196. CHAPTER 172
  197. CHAPTER 173
  198. CHAPTER 174
  199. CHAPTER 175
  200. CHAPTER 176
  201. CHAPTER 177
  202. CHAPTER 178
  203. CHAPTER 179
  204. EPILOGUE
  205. THE RELENTLESS PLAYLIST
  206. Acknowledgments
  207. Also by Jonathan Maberry
  208. ABOUT THE AUTHOR
  209. Newsletter Sign-up

Coleman held up a small white packet about half the size of a business card and less than half an inch thick. “According to their clinical records, something like this is intended to be surgically implanted just beneath the skin of each Fixer. And this is an expanded polytetrafluoroethylene pouch that contains hundreds of millions of cells.”

“What type of cells?” asked Church.

“Well, you see, boss, that’s the really interesting part. RNA-Seq showed that they were most likely chromaffin cells. Those are the cells in the adrenal cortex that are responsible for the release of catecholamines.”

“Cate…?” began Wilson, fumbling with it. Coleman stepped right in.

“Catecholamines are the molecules responsible for the body’s fight-or-flight response, which was interesting by itself. But when we dug down and did whole genome sequencing, we found a number of genetically inserted tet-on promoters. Specifically, they were attached to inserted versions of DOPA decarboxylase, dopamine β-hydroxylase, and phenylethanolamine N-methyltransferase.”

“I have no idea what that means.”

Coleman, who was in gear and very excited, tried to scale it down, but he was a lab rat and very rarely had to explain these things to ordinary mortals. “Tet-on promoters are a little bit of DNA that can be used to control when a gene is expressed. Think of it as a light switch for a gene. But this switch is flipped by adding tetracycline. It has been used in biotechnology for a long time, but this isn’t just some off-the-shelf version. This is highly specialized to turn on very fast and make huge amounts of the genes. And the genes they control are the genes in the synthetic pathway to turn L-Dopa into norepinephrine and adrenaline.”

“But … but…,” fumbled Nikki, “why put the cells in the pouches? Why not just inject them somewhere into the PMC?”

“Because the pouch protects the cells from the immune system of the person it is implanted into, so there is no rejection,” explained Coleman. “The pouch lets small molecules and liquid back and forth, but it doesn’t allow cells in or out. There is a clinical trial underway right now where similar technology is being used to encapsulate insulin-secreting cells to treat type 1 diabetes. However, in this case, they are using the pouches as small bioreactors to make huge amounts of norepinephrine and adrenaline but only in the presence of tetracycline. L-Dopa is a synthetic precursor for those hormones, so that makes sense, too.”

“Okay,” Nikki said. “I think I actually understood that part.”

“Still clinging on by my fingernails,” Wilson said under his breath.

“So the capsules under the skin are filled with cells that have been engineered so that the presence of this antibiotic causes them to create huge amounts of norepinephrine and adrenaline. The combination of those two hormones is what is believed to cause hysterical strength. That’s the kind of thing where a mom lifts a car off her baby or whatever.”