Seppuku's genetic template was first synthesized by Leslie Orgel18 back in 2000; TNA actually does duplex with conventional nucleic acids. The idea of alien genes incorporating themselves into our own nuclear material is even more old-hat than artificial microbes—not only are our genes rife with parasitic DNA from a range of bugs, but functional genes originally brought into the cell by the ancestors of our own mitochondria appear to have migrated into the nucleus19. Massive horizontal gene transfer between species has occurred throughout much of Earth's history20, and of course the symbiotic incorporation of small cells into larger ones has a long and honorable history reflected in every eukaryotic cell on the planet. (Back in Maelstrom I cited chloroplasts and mitochondria; apicoclasts are a related example, devolved endosymbionts found in Toxoplasma and Plasmodium21.)

Taka Ouellette's awed appreciation of proline as a metabolic catalyst will probably be a little behind the times by mid-century, since Movassaghi and Jacobsen have already pointed out the potential of such simple molecules to act as enzymes22.

The Chemistry of Character

Some readers may wonder if I have trouble distinguishing between personality and neurochemistry. It's a fair point, but don't blame me: blame the scientists who can't let a week go by without reporting yet more evidence that personality is just another word for biochemistry, albeit written in an exceedingly complex font (e.g. Hannuk Yaeger's propensity for violence, rooted in his monoamine oxidase levels23). Unless you're one of those Easter-bunny vitalists who believes that personality results from some unquantifiable divine spark, there's really no alternative to the mechanistic view of human nature.

A central tenet of the whole rifters saga—introduced in Starfish, and expanded in Maelstrom and Behemoth—is that false memories of abuse can cause neurological changes in the individual every bit as real as genuine memories can. That was pretty speculative when Starfish first came out, but recent research has added empirical evidence of this effect24,25.

Details on the care and feeding of sociopaths were largely taken from the work of Robert Hare26 and others27. ßehemoth's musings regarding the adaptive value of sociopathy in corporate settings may not be entirely off the mark, either26,2829 (And as these references should make clear, neither Ken Lubin nor Achilles Desjardins are sociopaths in the classic sense. More goes into such creatures than a mere absence of conscience.)

Maelstrom established that Guilt Trip took its lead largely from the genes of certain parasites which could alter the behavior of their hosts. The actual mechanism by which this occurred was not known when that book came out, although some had speculated that it occured right down at the neurotransmitter level. I hung Guilt Trip's hat on that hypothesis, and am now relieved to report that the gamble paid off: at least one such parasitic puppet-master works by screwing with its host's serotonin-producing neurons30.